Chamberlain is a city in the Great Lakes region of South Dakota. It is along the east bank of the Missouri River. Understand Get in Get around See Atka Lakota Museum and Cultural Center, 1301 N Main St, +1 605 234-3452. May-Oct: M-Sa 8AM-6PM, Su 9AM-5PM; Nov-Apr: M-Sa 8AM-5PM. Free South Dakota Hall of Fame, 1480 S Main St (I-90 Exit 263), +1 605 234-4216. Memorial Day-Labor Day: M-F 8AM-6PM, Sa-Su 9AM-5PM; Labor Day-Memorial Day: M-F 9AM-5PM. The official hall of fame of South Dakota. Free Do Buy Eat Drink Sleep Best Western Lee's Motor Inn, 220 W King Ave, +1 605 734-5575. Check-in: 2PM, check-out: 11AM. Connect Go next