East Tennessee is a region of Tennessee that covers roughly the eastern third of the state, generally locations east of the edge of the Cumberland Plateau.
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- Norris Dam The first Tennessee Valley Authority dam, has overlooks with great views of the dam, lake, and valley. Has Norris Dam State Park around the lake behind it. Exit Interstate 75 at exits 122 or 128
- Sunsphere A Knoxville landmark with its golden glass, and an observation deck.
- Rock City, Lookout Mountain, Ruby Falls Landmarks in Chattanooga, can be packaged together.
- Lost Sea America's largest underwater lake, in Sweetwater.
- Knoxville Ice Bears A hockey team in Knoxville.
- Coke Oven Museum, historic coal processing ovens, northwest of Dunlap.
- Tennessee Volunteers SEC college football team in Knoxville.
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- Middle Tennessee - The Middle Grand Division extends east from the Tennessee River including both the Central Basin and the Highland Rim. It is the state's most prosperous area, including cities such as Nashville.
- West Tennessee - The Western Grand Division extends west from the Tennessee River and is the northern boundary of the Mississippi Delta cultural region.