Greenville is the seat of Butler County in the River Heritage region of Alabama, USA. It is located along Interstate 65 between Fort Deposit and Georgiana. Understand Greenville Area Chamber of Commerce. Get in Get around See Architecture Greenville City Hall, 31.83°, -86.6228°. 2020-12-25 Buell–Stallings–Stewart House, 31.8308°, -86.6244°. 2020-12-25 W.S. Blackwell House, 31.8311°, -86.6247°. 2020-12-25 Do Ritz Theater. 2020-12-25 Buy Eat BBQ 65, +1 334-371-5826, goodbbq@centurytel.net. Drink Front Street Pub, +1 334 382-2909, frontstreetpub@hotmail.com. Sleep Sherling Lake Campground, +1 334 382-3638. Best Western, +1 334 382-9200. Comfort Inn, +1 334 383-9595. Days Inn, +1 334 382-3118. Hampton Inn, +1 334 382-9631. Go next