The Northeast Washington region has a lot to see and do.
The nearest airport with commercial service is the Spokane International Airport, just south of the region. There are no international flights to the airport, but there are several connections to some cities in the Western United States: see the Spokane article for details. Another option is driving from the Seattle-Tacoma International Airport which has much more direct flights, but the drive takes 5-6 hours.
US Highways 2 and 395 from Spokane. State Hwy 20 runs east-west though all three counties and connects Newport, Colville, and Republic.
Public transportation is negligible and the best way to get around is by car.
Coffee is hugely popular all across the Pacific Northwest including Northeast Washington. Look for small road side espresso stands even in small towns.
Like the rest of Washington State, microbreweries and beer in general is hugely popular, and the area has many to offer for beer enthusiasts. Some brews can only be found in local stores or bars (some notable brewers don't even bottle their product). Ask your servers for local beer recommendations and search out regional microbrews in stores.
Although Northeast Washington is not known as wine country, many Washington State wines are still and plentiful in restaurants and stores.