Itineraries in South America Crossing more than one country Buenos Aires to Machu Picchu overland by bus and train, Colombia to Patagonia overland crossing 6 countries, spanning over 10,000 kilometers Amazon River Voyage 8 days downstream and 14 days upstream La Redota Argentina National Route 40 (Argentina) Tren de las Sierras Bolivia El Choro Trek Jesuit Missions of the Chiquitos Brazil Caminhos do Imigrante Estrada Real Chile Carretera Austral Ecuador Quilotoa Loop Paraguay Along the Paraguay River Peru Ausangate circuit Inca Highlands Inca Trail Salkantay trail Santa Cruz Trek Uruguay Along the coast of Uruguay