South Central Iowa is in the Midwest region of the United States of America. Cities Albia Centerville Osceola Ottumwa Other destinations Understand This region includes the counties of Mahaska, Keokuk, Union, Clarke, Lucas, Monroe, Wapello, Ringgold, Decatur, Wayne, Appanoose, and Davis. Get in By train Amtrak (Amtrak code OSC). Get around See Do Eat Drink Stay safe Go next