San Luis is a town in Western Arizona. It is across the US-Mexico border from San Luis Rio Colorado, Sonora. Get in San Luis is at the southern terminus of US-95. Greyhound, 721 N Main St, 32.489683°, -114.78248°. As this just a pick-up and drop-off point, tickets should be purchased beforehand online or over the phone. Get around See Do Buy Eat Drink Sleep Go next